Publications Google Scholar publications Scopus publications ORCID Dr. Caroline E. Paul Pure research output Selected publications Holly A. Reeve,* Jake Nicholson, Farieha Altaf, Thomas H. Lonsdale, Janina Preissler, Lars Lauterbach, Oliver Lenz, Silke Leimkuehler, Frank Hollmann, Caroline E. Paul* and Kylie A. Vincent* A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H We demonstrate a recycling system for synthetic nicotinamide cofactor analogues using a soluble hydrogenase with turnover number of >1000 for reduction of the cofactor analogues by H2. Coupling this system to an ene reductase, we show quantitative conversion of N-ethylmaleimide to N-ethylsuccinimide. The biocatalyst system retained >50% activity after 7 h. Caroline E. Paul, Daniel Eggerichs, Adrie H. Westphal, Dirk Tischler, Willem J.H. van Berkel Flavoprotein monooxygenases: versatile biocatalysts Flavoprotein monooxygenases (FPMOs) are single- or two-component enzymes that catalyze a diverse set of chemo-, regio- and enantioselective oxyfunctionalization reactions. Lía Martínez-Montero, Dirk Tischler, Philipp Süss, Anett Schallmey, Maurice C. R. Franssen, Frank Hollmann and Caroline E. Paul* Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade We established a cascade for the asymmetric azidohydroxylation of styrene derivatives leading to chiral substituted 1,2-azido alcohols via enzymatic asymmetric epoxidation, followed by regioselective azidolysis, affording the azido alcohols with up to two contiguous stereogenic centers. Ruud A. Weusthuis, Pauline L. Folch, Ana Pozo-Rodríguez, Caroline E.Paul Applying non-canonical redox cofactors in fermentation processes We propose to apply non-canonical redox cofactors (NRCs) in metabolic networks: cofactors that channel electrons exclusively from substrate to product, forming orthogonal circuits for electron transfer. Flavoenzyme-mediated regioselective aromatic hydroxylation with coenzyme biomimetics ChemCatChem 2020, 12, 1368–1375 A. Guarneri, A.H. Westphal, J. Leertouwer, J. Lunsonga, M.C.R. Franssen, D.J. Opperman, F. Hollmann, W.J.H. van Berkel, C.E. Paul* Alternative coenzymes for biocatalysis Curr. Opin. Biotechnol. 2019, 60, 63–71 A. Guarneri, W.J.H. van Berkel, C.E. Paul* Synthetic biomimetic coenzymes and alcohol dehydrogenases for asymmetric catalysis Catalysts 2019, 9, Article 207 L. Josa-Culleré, A.S.K. Lahdenperä, A. Ribaucourt, G.T. Höfler, S. Gargiulo, Y.-Y. Liu, J.-H. Xu, J. Cassidy, F. Paradisi, D.J. Opperman, F. Hollmann*, C.E. Paul* Biocatalytic C=C bond reduction through carbon nanodot-sensitized regeneration of NADH analogues Angew. Chem. Int. Ed. 2018, 57, 13825–13828J. Kim, S.H. Lee, F. Tieves, D.S. Choi, F. Hollmann, C.E. Paul*, C.B. Park* Old Yellow Enzyme-catalysed asymmetric hydrogenation: linking family roots with improved catalysis Catalysts 2017, 7, Article 130 A. Scholtissek, D. Tischler, A.H. Westphal, W.J.H. van Berkel, C.E. Paul* Dr. Caroline E. Paul Associate Professor +31 15 27 87995 B58.C2.040 email twitter linkedin Deel deze pagina: Facebook Linkedin Twitter Email WhatsApp Deel deze pagina