Biocatalysis

The section Biocatalysis brings together scientists working on biocatalysis, enzymology, organic chemistry and biomedical research.

Essential for life, enzymes now also play an increasingly important role in the chemical and pharmaceutical industries, where they can provide tangible economic and environmental benefits, yet the scope of this area is far from reaching its true potential. Our research encompasses the entire spectrum of biocatalysis, from fundamental understanding of enzymes’ mechanisms to their practical application in organic synthesis, aspects which are both of crucial importance for fostering a greener future for industry. As a section, one of our key focusses is on developing practical and sustainable chemical synthesis powered by biocatalysis.

Our research projects are highly collaborative and leverage our combined expertise in bioinorganic spectroscopy, enzymology, synthetic method development, enzyme immobilization and enzyme engineering. Collectively, we have world-leading knowledge that allows us to go all the way from the discovery and characterization of novel enzymes to their bioinformatics-driven high-throughput engineering, resulting in new (chemo)biocatalytic methods for chemical synthesis.

In the area of biomedical research, we seek advanced solutions at the intersection of biocatalysis, imaging and targeted treatment through the design and development of innovative probes for combined diagnosis and therapy. This includes the integration of nanomaterials and the strategic use of radioisotopes to enhance synergistic potential.

Our section boasts state-of-the-art capabilities for biocatalysis research including biochemistry, molecular biology, analytical (GC(-MS), SFC-MS, HPLC, UV-VIS and EPR), organic chemistry facilities as well as specialized equipment for handling air-sensitive systems. The university NMR facility is under the administration of the section.

As a section we contribute to the education of BSc and MSc students in the area of Life Science and Technology (LST) and Molecular Science and Technology (MST). For openings on BSc and MSc research projects students are referred to the webpages on teaching of the individual group leaders. In addition, the annual Advanced Course on Biocatalysis is organized by the section already for many years under the auspices of BioTech Delft.