NWO LIFT grant for Carrol and Hoogenboom labs
An NWO-LIFT grant has been awarded to a consortium of researchers including Elizabeth Carroll and Jacob Hoogenboom from ImPhys. In the consortium, further comprising UMC Groningen and ImPhys spin-off Delmic BV, novel microscopy techniques will be used to better visualize and understand structural/functional properties in medical biology, and to create tissue atlases.
Using today’s workflows, it takes days to record areas of just a few square millimetres. Delft University of Technology and Delmic BV have built a faster microscope that can do the job in less than one hour. In this project, we will
- modify the chemical process used to prepare tissue, to optimize it for this microscope, and use probes used to identify biomolecules;
- generate workflows that start with a specific function in a living animal model (zebrafish) and end with FAST-EM analysis.
The techniques developed in this project will be generally applicable, making it possible to implement ‘Google tissue’ in biology (and medical biology) right across the board.
Image courtesy of nanotomy.org
