Publications

2024

E Kingma, F Dolsma, L M Iñigo De La Cruz, L Laan (2024)
Saturated Transposon Analysis in Yeast as a One-step Method to Quantify the Fitness Effects of Gene Disruptions on a Genome-Wide Scale
Plos One, in press

C Linne, E Heemskerk, J Zwanikken, D J Kraft#, L Laan# (2024)
Optimality and cooperativity in superselective surface binding by multivalent DNA nanostars
Soft Matter, 2024, https://doi.org/10.1039/D4SM00704B
# corresponding authors

MM Glazenburg, NM Hettema, L Laan, O Remy, G Laloux, T Brunet, X Chen, Y H Tee, W Wen, MS Rizvi, MK Jolly and M Riddell (2024)
Perspectives on polarity – exploring biological asymmetry across scales 
Journal of Cell Science (2024) 137, jcs261987. doi:10.1242/jcs.261987

S Tschirpke, WKG Daalman, L Laan (2024)
Quantification of GTPase cycling rates of GTPases and GTPase : effector mixtures using GTPase Glo™ assays
Current Protocols, doi: 10.1002/cpz1.1000

2023

F Brauns, LM Iñigo de la Cruz, WKG Daalman, ..., L Laan# and E Frey# (2023)
Redundancy and the role of protein copy numbers in the cell polarization machinery of budding yeast
Nature communications 14 (1), 6504
# corresponding authors

Enzo Kingma, Eveline T. Diepeveen, Leila M. Inigo de la Cruz and Liedewij Laan (2023)
Pleiotropy drives evolutionary repair of the responsiveness of polarized cell growth in Saccharomyces cerevisiae to environmental cues.
Frontiers in Microbiology Volume 14 - 2023 | doi: 10.3389/fmicb.2023.1076570
 
MM Glazenburg, L Laan (2023)
Complexity and self-organization in the evolution of cell polarization
Journal of cell science 136 (2), jcs259639
 
Meike Wortel, ….Liedewij Laan,…., Pleuni Pennings (2023)
Towards evolutionary predictions: Current promises and challenges.
Evolutionary applications 16 (1), 3-21
 
WKG Daalman, E Sweep, L Laan (2023)
A tractable physical model for the yeast polarity predicts epistasis and fitness.
Philosophical Transactions of the Royal Society B 378 (1877), 20220044                           

S Tschirpke, F van Opstal, R van der Valk, WKG Daalman, L Laan (2023)
A guide to the in vitro reconstitution of Cdc42 GTPase activity and its regulation
bioRxiv, 2023.04. 24.538075

2022

WKG Daalman, L Laan (2022)
Epigenetic feedback on noisy expression boosts evolvability
bioRxiv, 2022.06. 29.498068

David Zwicker and Liedewij Laan (2022)
Evolved interactions stabilize many coexisting phases in multicomponent liquids
Proc Natl Acad Sci, 119 (28) e2201250119 https://doi.org/10.1073/pnas.2201250119

2020

Werner Karl-Gustav Daalman, Els Sweep, Liedewij Laan (2020)
The Path towards Predicting Evolution as Illustrated in Yeast Cell Polarity.
Cells 2020, 9(12), 2534; https://doi.org/10.3390/cells9122534

Philippe Nghe*, Marjon de Vos*, Enzo Kingma*, Manjunatha Kogenaru, Frank Poelwijk, Liedewij Laan, Sander Tans (2020)
Predicting evolution using regulatory architecture.
Annu Rev Biophys , Feb 4. doi: 10.1146/annurev-biophys-070317-032939 (*equal contribution)

2019

Kim Vendel*, Sophie Tschripke*, Fayezeh Shamsi, Marileen Dogterom and Liedewij Laan (2019)
Minimal in vitro systems shed light on cell polarity.
Journal of Cell Science, 132: jcs217554 doi:10.1242 (*equal contribution)

2018

Ivan Jelenic, Anna Selmecki, Liedewij Laan*, and Nenad Pavin* (2018)
Spindle dynamics model explains chromosome loss rates in yeast polyploid cells.
Frontiers in Genetics, 10.3389/fgene.2018.00296 (*corresponding authors)

Richard Janissen*, Mathia M. A. Arens*, Natalia N. Vtyurina*, Zaïda Rivai, Nicholas D. Sunday, Behrouz Eslami-Mossallam, Alexey A. Gritsenko, Liedewij Laan, Dick de Ridder, Irina Artsimovitch, Nynke H. Dekker*, Elio A. Abbondanzieri*, and Anne S. Meyer*
Dps and DNA form a dynamic, phase-separated organelle orthogonal to transcription.(2018)
Cell, 174, 1–12, https://doi.org/10.1016/j.cell.2018.06.049

Eveline T. Diepeveen, Valerie Pourquié, Thies Gehrmann, Thomas Abeel and Liedewij Laan (2018)
Patterns of conservation and diversification in the fungal polarization network.
Genome Biology and Evolution, evy121, https://doi.org/10.1093/gbe/evy121

2017

Eveline T. Diepeveen, Leila Iñigo de la Cruz, and Liedewij Laan (2017)
Evolutionary dynamics in the fungal polarization network, a mechanistic perspective.
Biophysical Reviews 1-13 /doi/10.1007/s12551-017-0286-2

Marian Baclayon, Svenja-Marei Kalisch, Ed Hendel, Liedewij Laan, Julien Husson, E Laura Munteanu, Marileen Dogterom (2017)
Optical Tweezers-Based Measurements of Forces and Dynamics at Microtubule Ends.
Optical Tweezers: Methods and Protocols, 411-435

2015

Wolfram Moebius and Liedewij Laan (2015)
Physical and Mathematical Modeling in Experimental Papers.
Cell, 163-7, 1577–1583
      Leading Edge Featured Article in Cell
      Blogpost about this paper
      highlight on the HFSP website

Liedewij Laan, John H. Koschwanez, Andrew W. Murray (2015)
Evolutionary recovery after crippling cell polarization reveals reproducible trajectories.
eLife, 10.7554/eLife.09638
      Featured by faculty of 1000
      Dispatch in Current Biology: Adaptive Evolution: don't fix what is broken
      Blogpost how yeast makes the best of what they got
      highlight on the HFSP website

Before TU Delft

Liedewij Laan (2014)
Experiments inside a box lead to out-of-the-box ideas on cellular organization.
Systems and Synthetic Biology, 1-4

Sophie Roth, Liedewij Laan and Marileen Dogterom (2014)
Reconstitution of cortical dynein function.
Meth of Enzymology: "Reconstituting the Cytoskeleton"

Rui Ma, Liedewij Laan, Marileen Dogterom, Nenad Pavin, Frank Jülicher (2014)
General theory for the mechanics of confined microtubule asters.
New J Phys, 16: 013018

Nenad Pavin*, Liedewij Laan*, Rui Ma, Marileen Dogterom, and Frank Jülicher (2012)
Positioning of microtubule organizing centers by cortical pushing and pulling forces.
New J. Phys. , 14: 105025 (*equal contribution)

Liedewij Laan , Sophie Roth, and Marileen Dogterom (2012)
End-on microtubule-dynein interactions and pulling-based positioning of microtubule organizing centers.
Cell Cycle, 11:20:3750–3757

Liedewij Laan, Nenad Pavin, Julien Husson, Guillaume Romet-Lemonne, Martijn van Duijn, Magdalena Preciado López, Ronald D. Vale, Frank Juelicher, Samara L. Reck-Peterson and Marileen Dogterom (2012)
‘Cortical’ Dynein Controls Microtubule Dynamics and Length, Generating Pulling Forces that Position Microtubule Asters.
Cell, 148: 502–514
      Featured Article in Cell
      Featured by faculty of 1000
      Paperclip in Cell
      Discussed in NRC Handelsblad, Saturday February 4th 2012

Svenja-Marei Kalisch, Liedewij Laan and Marileen Dogterom (2011)
Force generation by dynamic microtubules in vitro.
Methods Mol Biol, 777: 147-65

Liedewij Laan and Marileen Dogterom (2010)
In vitro assays to study force generation at dynamic microtubule ends.
Methods Cell Biol , 95: 617-39

Julien Husson, Liedewij Laan, Marileen Dogterom (2009)
Force-generation by microtubule bundles.
Biophysical Reviews and Letters, 4: 33-44

Liedewij Laan*, Julien Husson*, E. Laura Munteanu, Jacob W. J. Kerssemakers, Marileen Dogterom (2008)
Force-generation and dynamic instability of microtubule bundles.
Proc Natl Acad Sci, 105:8920-8925 (*equal contribution)

Peter Bieling*, Liedewij Laan*, Henry Schek, E. Laura Munteanu, Linda Sandblad, Marileen Dogterom, Damian Brunner, Thomas Surrey (2007)
Reconstitution of a microtubule plus-end tracking system in vitro.
Nature, 450: 1100-1105 (*equal contribution)
      Featured by faculty of 1000

Marileen Dogterom, Julien Husson, Liedewij Laan, E. Laura Munteanu, Christian Tischer
Microtubule forces and organization.
Cell motility / ed. P. Lenz. - New York : Springer, 2007. pp. 93-115 (Springer series in Biological and Medical Physics, Biomedical Engineering)

Jacob W. J. Kerssemakers, E. Laura Munteanu, Liedewij Laan, Tim Noetzel, Marcel Janson and Marileen Dogterom (2006)
Assembly dynamics of microtubules at molecular resolution.
Nature, 442: 709-712
      Featured by faculty of 1000