Research

Within the Center for Safety in Healthcare, versatile research is conducted together with hospitals and other healthcare institutions. The team focuses on various themes such as optimization of processes, safety culture, professional conduct, safe introduction of new technology and works on developing / improving research methods.

Current projects

Anticancer: Game Theory Empowered by Data Science and Control Theory to Improve Treatment of Metastatic Cancer

January 2023 – December 2027

This research investigates novel game theoretic models and combines these with data science and control theory to improve standard of care in cancer treatment. With these models a physician will be able to anticipate the cancer cells’ response to the treatment and subsequently steer the eco-evolutionary dynamics of the cancer cells towards better patient outcomes.

Publications

2024

Van de Voort I, Grossmann I, Leistikow I, Weenink JW. What’s up doc? Physicians’ reflections on their sustainable employability throughout careers: a narrative inquiry. BMC Health Serv Res 2024;24:539 doi: 10.1186/s12913-024-10924-1.

Geurkink TH, Marang-van de Mheen PJ, Nagels J, Robbers T, Nelissen RGHH. Long-term outcomes of pectoralis major transfer for scapular winging due to long thoracic nerve palsy: results after a median follow-up of 17 years. J Elbow Shoulder Surg 2024 (in press).

Bos K, van der Laan MJ, Groeneweg J, Kamps GJ, Legemate DA, Leistikow I, Dongelmans DA. Grading recommendations for enhanced patient safety in sentinel event analysis: the recommendation improvement matrix. BMJ open quality. 2024;13:e002592.

Kuhrij LS, Marang-van de Mheen PJ, van Lier L, Alimahomed R, van Bodegom-Vos L. Reduction in use of MRI and arthroscopy among patients with degenerative knee disease in private clinics versus public hospitals – a time series analysis. Int J Qual Health Care 2024;36:mzae004.

Van der Lelij TJN, Marang-van de Mheen PJ, Kaptein BL, Nelissen RGHH. Failure of Screw/Shell Interface in Trident II Acetabular System in Total Hip Arthroplasty. Arthroplasty Today 2024 Epub April 24.

Van der Lelij TJN, Koster LA, Marang-van de Mheen PJ, Toksvig-Larsen S, Nelissen RGHH, Kaptein BL. Influence of marker-selection method on mean tibial baseplate migration and individual migration patterns in TKA in marker-based RSA. A re-analysis of a RCT with 5 year follow-up. Acta Orthoped 2024;95:157–165.

Kruiswijk AA, van de Sande MAJ, Verhoef C, Schrage YM, Haas RL, Bemelmans MHA, van Ginkel RJ, Bonenkamp JJ, Witkamp AJ, van den Akker-van Marle ME, Marang-van de Mheen PJ, van Bodegom-Vos L. Health-related quality of life following surgery in patients with high-grade extremity sarcoma: a prospective longitudinal study. Cancers 2024;16:547.

Browne JP, Franklin BD, Thomas EJ, Marang-van de Mheen PJ. Our mission and how we hope to move the field forward: statement from the BMJ Quality & Safety senior editorial team 2023. BMJ Qual Saf 2024;33:141-4.

Hasan S, van Schie P, Kaptein BL, Schoones JW, Marang-van de Mheen PJ, Nelissen RGHH. Biomarkers to discriminate between aseptic loosened and stable total hip and knee arthroplasties. A systematic review. EFORT Open Rev 2024;9:25-39.

Van der Lelij TJN, Marang-van de Mheen PJ, Kaptein BL, Koster LA, Ljung P, Nelissen RGHH, Toksvig-Larsen S. Migration and clinical outcomes of a 3D-printed versus conventionally manufactured cementless acetabular cup: Two-year follow-up of a randomized controlled trial using radiostereometric analysis. BJJ 2024;106-B(2):136-43.

Marang-van de Mheen PJ, Thomas EJ, Graber ML. How safe is the diagnostic process in healthcare? BMJ Qual Saf 2024;33:82-5.

2023

Van Kampen J, Lammers M, Steijn W, Guldenmund F, Groeneweg J. What works in safety: The use and perceived effectiveness of 48 safety interventions. Saf Science 2023;162:106072.

Van der Beek D, Steijn WMP, Groeneweg J. Intervention Mapping as a Framework for Developing and Testing an Intervention to Promote Safety at a Rail Infrastructure Maintenance Company. Safety 2023 Epub August 10;9:55.

Tresfon J, Langeveld K, Brunsveld-Reinders AH, Hamming J. Coming to Grips-How Nurses Deal With Restlessness, Confusion, and Physical Restraints on a Neurological/Neurosurgical Ward. Glob Qual Nurs Res. 2023 Jan 24;10:23333936221148816. doi: 10.1177/23333936221148816.

Hoogervorst LA, Geurkink TH, Lubbeke Wolf A, Buccheri S, Schoones J, Torre M, Laricchiuta P, Piscoi P, Pedersen AB, Gale CP, Smith JA, Maggioni AP, James S, Fraser AG, Nelissen RGHH, Marang-van de Mheen PJ. Quality of European cardiovascular and orthopaedic registries for the regulatory evaluation of medical device safety and performance across the implant lifecycle: a systematic review. Int J Health Policy Manag 2023;12:7648.

Marang-van de Mheen PJ, Woodcock T. Grand rounds in methodology: four critical decision points in Statistical Process Control evaluations of Quality Improvement initiatives. BMJ Qual Saf 2023;32:47-54.

Verhagen MJ, de Vos MS, van Schaik J, van der Vorst JR, Schepers A, Marang-van de Mheen PJ, Hamming JF. Surgical team dynamics in a reflective team meeting to improve quality of care: a qualitative analysis of a shared mental model. Br J Surg 2023;110:1271-5.

Marang-van de Mheen PJ, Vincent C. Measuring what matters – refining our approach to quality indicators. BMJ Qual Saf 2023;32:305-8.

Tresfon J

, Nollen JM, Brunsveld-Reinders, A. Aanpassingen bij medicatietoediening. TVZ verpleegkd prakt wet 2023;133:36–40. doi.org/10.1007/s41184-023-1921-y.

Weenink JW, Tresfon J, van de Voort I, van Muijden T, Hamming J, Bal R. Room for resilience: a qualitative study about accountability mechanisms in the relation between work-as-done (WAD) and work-as-imagined (WAI) in hospitals. BMC Health Serv Res. 2023 Sep 30;23(1):1048. doi: 10.1186/s12913-023-10035-3. PMID: 37777751;

Huizing F, Sier VQ, Tresfon JAS, van der Vorst JR, Liem RSL, Schmitz RF, Schepers A, Houwert RM, Vriens MR, Snijders HS, Blok JJ. Future surgeon: bridging the intergenerational gap. Br J Surg. 2023 Jul 17;110(8):991-992. doi: 10.1093/bjs/znad118.

Geurkink TH, Marang-van de Mheen PJ, Nagels J, Poolman RW, Nelissen RGHH, van Bodegom-Vos L. Substantial variation in decision-making to perform subacromial decompression surgery for subacromial pain syndrome between orthopedic shoulder surgeons for identical clinical scenarios. A case-vignette study. Arthroscopy, Sports Medicine, Rehabilitation 2023;5:100819.

Kruiswijk AA, van de Sande MAJ, Haas RL, van den Akker-van Marle EM, Engelhardt EG, Marang-van de Mheen PJ, van Bodegom-Vos L. (Cost-)effectiveness of an individualized risk prediction tool (PERSARC) on patient’s knowledge and decisional conflict among soft tissue sarcomas patients: study protocol for a parallel clustered randomized trial (the VALUE-PERSARC study). BMJ Open 2023 Nov 2;13(11):e074853.

Kruiswijk AA, Kuhrij-Kingma LS, Dorleijn DMJ, van de Sande MAJ, Bodegom-Vos L, Marang-van de Mheen PJ. Follow-up after curative surgical treatment of soft-tissue sarcoma for early detection of recurrence: which patients have more or fewer visits than advised in guidelines? Cancers 2023;15(18):4617.

Hoogervorst LA, Stijnen P, Albini M, Janda N, Stewardson AJ, Patel K, Nelissen RGHH, Marang-van de Mheen PJ. Clinical outcomes of non-COVID-19 orthopaedic patients admitted during the COVID-19 pandemic: a multi-centre interrupted time series analysis across hospitals in six different countries. BMJ Open 2023;13(9):e073276.

Alimohamad H, Yilmaz D, Marang-van de Mheen PJ, Jansen J, Hamming JF, Schepers A. Predictors for postoperative cranial nerve complications in carotid body tumor resection: a retrospective cohort study. Int J Surg 2023;109:4057-61.

Geurkink TH, Marang-van de Mheen PJ, Nagels J, Poolman RW, Nelissen RGHH, van Bodegom-Vos L. Impact of active disinvestment on decision-making for surgery in patients with subacromial pain syndrome. A qualitative semi-structured interview study among hospital sales managers and orthopedic surgeons. Int J Health Policy Manag 2023;12:7710.

Van der Lelij TJN, Marang-van de Mheen PJ, Kaptein BL, Toksvig-Larsen S, Nelissen RGHH. Continued stabilization of a cementless 3D-printed total knee arthroplasty: 5-year results of a randomized controlled trial using radiostereometric analysis. JBJS 2023;105:1686-94.

Geurkink TH, van Bodegom-Vos L, Nagels J, Liew S, Nelissen RGHH, Marang-van de Mheen PJ. The relationship between publication of high-quality evidence and changes in the volume and trend of subacromial decompression surgery for patients with subacromial pain syndrome in hospitals across Australia, Europe and the United States: A controlled interrupted time series analysis. BMC Musculoskel Dis 2023;24(1):456.

Geurkink TH, Overbeek CL, Marang-van de Mheen PJ, Nagels J, de Groot JH, Nelissen RGHH. Ageing and joint position sense of the asymptomatic shoulder: an observational study. JEK 2023 Epub May 29;71:102792.

Kruiswijk AA, Dorleijn DMJ, Marang-van de Mheen PJ, van de Sande MAJ, van Bodegom-Vos L. Health-related quality of life of bone and soft-tissue tumor patients around the time of diagnosis. Cancers 2023;15:2804.

Van der Heijden LLM, Marang-van de Mheen PJ, Thielman L, Stijnen P, Hamming JF, Fourneau I. Validity of routinely reported Rutherford scores by clinicians as part of daily clinical practice. Int J Angiol 2023 Epub Feb 25.

Akpinar EO, Liem RSL, Nienhuijs SW, Greve JWM, Marang-van de Mheen PJ. Weight recurrence after Sleeve Gastrectomy versus Roux-en-Y gastric bypass: a propensity score matched nationwide analysis. Surg Endosc 2023;37:4351-9.

Geurkink TH, Gacaferi H, Marang-van de Mheen PJ, Schoones JW, de Groot JH, Nagels J, Nelissen RGHH. Treatment of neurogenic scapular winging: a systematic review on outcomes after non-surgical management and tendon transfer surgery. J Elbow Shoulder Surg 2023;32:e35-e47.

Akpinar EO, Liem RSL, Nienhuijs SW, Ghaferi A, Bonham AJ, Greve JWM, Marang-van de Mheen PJ. Predicting serious complications risks after bariatric surgery: external validation of the Michigan Bariatric Surgery Collaborative (MBSC) risk prediction model using the Dutch Audit for Treatment of Obesity. SOARD 2023;19:212-21.

Marang-van de Mheen PJ, Browne JP, Thomas EJ, Franklin BD. Grand Rounds in Methodology: a new series to contribute to continuous improvement of methodology and scientific rigor in quality and safety. BMJ Qual Saf 2023;32:13-6.

Hoogervorst LA, van Schie P, Nagels J, Nelissen RGHH, Marang-van de Mheen PJ. The reliability of revision rates following primary shoulder arthroplasty as quality indicator to rank hospital performance: a national registry analysis including 13,104 shoulders and 87 hospitals. J Elbow Shoulder Surg 2023;32:59-67.

Van Schie P, van Bodegom-Vos L, Zijdeman TM, Nelissen RGHH, Marang-van de Mheen PJ. Effectiveness of a multifaceted quality improvement intervention to improve patient outcomes after Total Hip and Knee Arthroplasty: A registry nested cluster randomised controlled trial. BMJ Qual Saf 2023;32:34-46.

2022

Tresfon J, Brunsveld-Reinders AH, van Valkenburg D, Langeveld K, Hamming J. Aligning work-as-imagined and work-as-done using FRAM on a hospital ward: a roadmap. BMJ Open Qual. 2022 Oct;11(4):e001992. doi: 10.1136/bmjoq-2022-001992.

Becherer BE, Marang-van de Mheen PJ, Young-Afat DA, van der Hulst RRJW, Keuter XHA, Rakhorst HA, Mureau MAM. Variation in the use of infection control measures and infection-related revision incidence after breast implant surgery in the Netherlands. JPRAS Open 2022;34:226-38.

Akpinar EO, Liem RSL, Nienhuijs SW, Greve JWM, Marang-van de Mheen PJ. Hospital variation in preference for a specific bariatric procedure and the association with weight loss performance: a nationwide analysis. Obes Surg 2022;32:3589-99.

Akpinar EO, Nienhuijs SW, Liem RSL, Greve JWM, Marang-van de Mheen PJ. Conversion to RYGB versus OAGB after failed primary gastric band: a matched nationwide study. SOARD 2022;18:948-56.

Rietbergen T, Marang-van de Mheen PJ, de Graaf J, Diercks RL, Janssen RPA, van der Linden-van der Zwaag HMJ, van den Akker-van Marle ME, Steyerberg EW, Nelissen RGHH, van Bodegom-Vos L. A tailored intervention does not reduce low value MRI's and arthroscopies in degenerative knee disease when the secular time trend is taken into account: difference-in-difference analysis. Knee Surg Sports Traumatol Arthrosc 2022;30:4134-43.

Van Bodegom-Vos L, Marang-van de Mheen PJ. Reducing low-value care: uncertainty as the crucial cross-cutting theme. Int J Health Policy Manag 2022;11:1964-6.

Van Schie P, Hasan S, van Bodegom-Vos L, Schoones JW, Nelissen RGHH, Marang-van de Mheen PJ. International comparison of variation in performance between hospitals for THA and TKA: Is it even possible? A systematic review including 33 studies and 8 arthroplasty register reports. EFORT Open rev 2022;7:247-63.

Hasan S, Kaptein BL, Marang-van de Mheen PJ, van Hamersveld KT, Nelissen RGHH, Toksvig-Larsen S. Late stabilization of initial migration following cemented total knee arthroplasty. A 5-year follow-up paper of two randomized controlled trials using radiostereometric analysis. Acta Orthoped 2022; 93: 271–276.

Kuhrij L, Marang-van de Mheen PJ. Adding value to the diagnostic process. BMJ Qual Saf 2022;31:489-92.

Van Schie P, van Bodegom-Vos L, Steenbergen L, Nelissen RGHH, Marang-van de Mheen PJ. A more comprehensive evaluation of delivered care after total hip and knee arthrosplasty. Combining indicators reliably in an ordered composite outcome. Acta Orthoped 2022;93:138-45.

Rietbergen T, Marang-van de Mheen PJ, Diercks RL, Janssen RPA, van der Linden-van der Zwaag HMJ, Nelissen RGHH, Steyerberg EW, van Bodegom-Vos L. Performing a knee arthroscopy among patients with degenerative knee disease: one-third is potentially low value care. Knee Surg Sports Traumatol Arthrosc 2022;30: 1568-74.

Dyreborg J, Lipscomb HJ, Nielsen K, Törner M, Rasmussen K, Frydendall KB, Bay H, Gensby U, Bengtsen E, Guldenmund F, Kines P. Safety interventions for the prevention of accidents at work: A systematic review. Campbell systematic reviews 2022;18:1234.

Guldenmund F. Veiligheidskundige, wat bezielt je? Drijfveren door de tijd heen. NVVK Info. 2022;31:6-8.

Guldenmund F, Bus J. Ik leg het nog één keer uit!’: Louis van Gaal voor veiligheidskundigen. NVVK Info 2022;31:14-16.

Guldenmund F, Bus J, Balm M, Heerkens Y. Samenvatting handreiking Groeien in arbeidsveiligheid: Zeven stappen voor betere veiligheidsprestaties. Sociaal-Economische Raad 2022.

Casey TW, Hu X, Reid C, Tran PA, Guldenmund F. Rolling up our sleeves and pulling up our socks: A critical review of safety culture definitions and measures, and innovative ways to move the field forward. Handbook of Research Methods for Organisational Culture 2022;291-311.

Van Dongen D, Guldenmund F, Groeneweg J, Grossmann I, Roelofsma P, Luijcks N. Learning from speaking up by learning to speak up. Safety Management and Human Factors 2022;64.

Guldenmund F, Groeneweg J, Grossmann I, Roelofsma P, van Dongen D, Luijcks N. What is the Meaning of Safety in the Context of Health Care? 2022.

Burggraaf J, Groeneweg J, Sillem S, van Gelder P. What employees do today because of their experience yesterday: Previous exposure to yellow: number aspects as a cause for SPAD incidents. Journal of Rail Transport Planning & Management 2022 Epub September 1;23:100332.

Reijmerink IM, Bos K, Leistikow IP, Groeneweg J, Cnossen F, Dongelmans DA, van der Laan MJ. Performance variability in perioperative sentinel events: report on a nationwide data set. British Journal of Surgery 2022 Epub July 1;109: 573-575.

Burggraaf J, Groeneweg J, Sillem S, van Gelder P. Journal of Rail Transport Planning & Management. Journal of Rail Transport Planning and Management 2022;23: 100332.