Publications

• 2024

  Live-cell imaging reveals the trade-off between target search flexibility and efficiency for Cas9 and Cas12a

  Lorenzo Olivi / Cleo Bagchus / Victor Pool / Ezra Bekkering / Konstantin Speckner / Hidde Offerhaus / Wen Y. Wu / Martin Depken / Koen J.A. Martens / Raymond H.J. Staals / Johannes Hohlbein

• 2023

  Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex

  Misha Klein / Subhas C. Bera / Thomas K. Anderson / Bing Wang / Flavia S. Papini / Jamie J. Arnold / Craig E. Cameron / Martin Depken / David Dulin / More Authors

• 2022

  A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity

  Behrouz Eslami-Mossallam / Misha Klein / Constantijn V.D. Smagt / Koen V.D. Sanden / Stephen K. Jones / John A. Hawkins / Ilya J. Finkelstein / Martin Depken

• 2022

  High-throughput single-molecule experiments reveal heterogeneity, state switching, and three interconnected pause states in transcription

  Richard Janissen / Behrouz Eslami-Mossallam / Irina Artsimovitch / Martin Depken / Nynke H. Dekker

• 2022

  Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter

  Subhas C. Bera / Pim P.B. America / Santeri Maatsola / Mona Seifert / Eugeniu Ostrofet / Jelmer Cnossen / Monika Spermann / Martin Depken / David Dulin / More Authors

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