Dr.ir. A. (Aswin) Muralidharan
Dr.ir. A. (Aswin) Muralidharan
Profile
Biografie
Aswin Muralidharan is a postdoctoral researcher with Prof. Stan Brouns (Department of Bionanoscience). His current research interest lies in interactions of bacteria and bacteriophages and in developing programmable cancer therapeutics. He received prestigious individual grants from KWF, NWO and Delft Health Initiative to pursue development of novel programmable therapeutics which can be activated upon sensing oncogenic mutations in cancer cells.During his PhD, he studied gene delivery to mammalian cells using pulsed electric fields with Prof. Michiel Kreutzer and Dr. Pouyan Boukany at Delft University of Technology in collaboration with Univerza v Ljubljani and Universiteit Bremen.
Aswin was trained as a chemical engineer, and obtained his master’s degree cum laude in chemical engineering studying cardiovascular flow measurements with advanced imaging and computational techniques under Prof. Sasa Kenjeres (Transport Phenomena Research Group) in collaboration with Erasmus Medical Center Rotterdam. He also obtained an additional honours degree in research during his masters degree for studying single molecule biophysics of DNA stretching under the supervision of Dr. Pouyan Boukany.
Expertise
Single molecule biophysics, bacteria-bacteriophage interactions
Expertise
Publications
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2024
Electrotransfer for nucleic acid and protein delivery
A. Muralidharan / P. Boukany
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2021
Actin networks regulate the cell membrane permeability during electroporation
Aswin Muralidharan / Lea Rems / Michiel T. Kreutzer / Pouyan E. Boukany
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2022
Microtrap array on a chip for localized electroporation and electro-gene transfection
A. Muralidharan / G.R. Pesch / H.M.K. Hubbe / Lea Rems / M. Nouri Goushki / P. Boukany
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2022
A Programmable Multifunctional 3D Cancer Cell Invasion Micro Platform
Qian Liu / Aswin Muralidharan / Abtin Saateh / Zhaoying Ding / Peter ten Dijke / Pouyan E. Boukany
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2022
Models of electroporation and the associated transmembrane molecular transport should be revisited
M. Scuderi / J. Dermol-Černe / C. Amaral da Silva / A. Muralidharan / P. Boukany / Lea Rems
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Prizes
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2024-3-1
Kankertherapie gericht op specifieke oncogenen door het gebruik van CRISPR-guided Caspase
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2023-6-1
Using bacterial defence machinery for selective killing of cancer cells
Ancillary activities
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2023-10-06 - 2025-10-06