Prof. dr. Freek J. Beekman

Prof. Freek Beekman is head of the section Biomedical Imaging at Delft University of Technology. He (co-)authored ~165 peer reviewed journal papers, several book chapters and is the inventor of more than 20 patent families. He was presented with many awards for his scientific contributions and innovations in biomedical imaging. His research interests include development of detectors, improved image reconstruction algorithms for PET, SPECT and X-ray CT, the development of hybrid photonic imaging devices and AI applied to nuclear imaging. Freek is a board member of Biomedical Engineering and IEEE Transaction on Medical Imaging. Freek won with the NWO  Physics Valorization Prize, the Innovation of the Year Award by the World Molecular Imaging Society (in 2015 for ultra-high resolution clinical SPECT, and in 2018 for Broadband Photonic Tomography. In 2017 he was presented the Edward Hoffman Memorial Award and in 2021 the Bruce Hasegawa Memorial Award. Freek is the founder of MILabs BV (www.milabs.com) that develops and markets high performance images systems and served as MILabs CEO from 2006 to 2021 when he successfully sold MILabs to Rigaku in Japan. Today the systems that are developed by Freek and his teams at TU Delft and MILabs are in use in many premier biomedical research institutions worldwide including academic institutions and the largest blue chip pharma companies. These systems have resulted in many interesting discoveries and support development of new tracers and pharmaceuticals.

Selected publications  

  • A scanning focus nuclear microscope with multi-pinhole collimation. M.P. Nguyen, M Arif, B Oostenrijk, M C Goorden, F J Beekman. Phys. Med.BIol. 2023

  • Glymphatic-enhanced brain delivery of nanoparticles: A new therapeutic approach T.O. Lilius, K. Nygaard Mortensen, C. Devile, T. J. Lohela, F. F. Stæger, B. Sigurdsson, E. M. Fiordaliso, M. Rosenholm, C. Kamphuis, F. J. Beekman, A. I. Jensen, M. Nedergaard, J. Controlled Release, 2023

  • Evaluating the Targeting of a Staphylococcus-aureus-Infected Implant with a Radiolabeled Antibody In Vivo. B. van Dijk, J F Hooning van Duyvenbode, L. de Vor, F R H A Nurmohamed, M G E H Lam 3, A J Poot, R M Ramakers, S Koustoulidou, F J Beekman, J. van Strijp, S H M Rooijakkers, E Dadachova, H C Vogely, H Weinans, B C H van der Wal,  Int.J.Mol.Sci. 2023

  • Convolutional neural network based attenuation correction for 123I-FP-CIT SPECT with focused striatum imaging. Y. Chen, M.C. Goorden and F.J. Beekman, Phys . Med. Biol, 2021

  • Topographic features of nano-pores within the osteochondral interface and their effects on transport properties –a 3D imaging and modeling study. B. Pouran, A. Raoof, D.A. M. de Winter, V. Arbabi, R.L.A.W Bleys, F.J. Beekman, A.A. Zadpoor, J. Malda, H. Weinans, Journal of Biomechanics, 2021

  • Human monoclonal antibodies against Staphylococcus aureus surface 4 antigens recognize in vitro biofilm and in vivo implant infections. L. de Vor, B van Dijk, K.P.M. van Kessel1, J. S. Kavanaugh7, C. J.C. de Haas , Piet C. Aerts, Marco C. Viveen, Edwin C.H. Boel, Ad C. Fluit, Jakub M. Kwiecinski, G. C. Krijger, R. M. Ramakers, F. J. Beekman, E. Dadachova, M. G.E.H. Lam, H. C. Vogely, B. C.H. van der Wal, J. A.G. van Strijp, A. R. Horswill, H. Weinans, S. H.M. Rooijakkers. eLife, 2021

  • Positron Range-Free and Multi-Isotope Tomography of Positron Emitters. F.J. Beekman, C. Kamphuis, S. Koustoulidou, R.M. Ramakers, M.C. Goorden, Phys Med. Biol. 2021

  • Automatic attenuation map estimation from SPECT data only for brain perfusion scans using convolutional neural networks, Y. Chen, M.C. Goorden, F.J. Beekman, Phys Med. Biol. 2021

  • EXIRAD-HE: multi-pinhole high-resolution ex vivo imaging of high-energy isotopes. M.P.  Nguyen, M.C. Goorden, F.J. Beekman, Phys. Med.Biol. 2021

  • The clinical utilities of multi-pinhole single photon emission computed tomography. I. Ozsahin, L. Chen, A. Könik, M.A. King, F.J. Beekman, G.S.P. Mok, Quant Imaging Med Surg, 2006-2029, 2020

  • Characterization of a multi-pinhole molecular breast tomosynthesis scanner" by B. Wang,  J van Roosmalen, R. Kreuger, J. Huizenga, F.J. Beekman, M.C. Goorden, Phys Med. Biol. 2020

  • Accelerated image reconstruction by a combined dual-matrix dual-voxel approach" , M.C. Goorden, C. Kamphuis, R.M.  Ramakers, F.J. Beekman, Phys Med. Biol. 2020.

  • Optimized sampling for high resolution multi-pinhole brain SPECT with stationary detectors.

  • Chen Y, Goorden MC, Vastenhouw B, Beekman FJ. Phys Med Biol. 2020

  • Optimized Image Acquisition for Dopamine Transporter Imaging with Ultra-high Resolution Clinical Pinhole SPECT. Y. Chen, B. Vastenhouw, C. Wu, M. C. Goorden, F. J. Beekman, Phys.Med.Biol. 2018

  • Comparison of fan-beam, slit-slat and multi-pinhole collimators for molecular breast tomosynthesis" J. van Roosmalen, F.J. Beekman, M.C. Goorden, Phys Med. Biol. 2018

  • System geometry optimization for Molecular Breast Tomosynthesis with focusing multi-pinhole collimators. J. van Roosmalen, L. Piët; M. van Schie; F.J. Beekman, M.C. Goorden. Phys Med. Biol. 2017

  • Voxelized ray-tracing simulation dedicated  to multi-pinhole molecular breast tomosynthesis" by B. Wang, J. van Roosmalen, L. Piët; M. van Schie; F.J. Beekman, M.C. Goorden, Biomedical Physics & Engineering Express, 2017

  • Molecular breast tomosynthesis with scanning focus multi-pinhole cameras. van Roosmalen J, Goorden MC, Beekman FJ. Phys Med Biol. 2016 Aug 7;61(15):5508-28

  • Similarity-regulation of OS-EM for accelerated SPECT reconstruction. P.E.B. Vaissier, F J Beekman, and M C Goorden, Phys. Med. Biol. 2016

  • High-resolution clusterd-pinhole 131-I SPECT imaging in mice, F. van der Have, O. Ivaschchenko, M.C. Goorden, R.M. Ramakers, F.J. Beekman, Nucl. Med. & Biol., 2016

  • Utilizing high-energy gamma photons for high-resolution 213-Bi SPECT in mice. J. de Swart, H.S. Chan, M.C. Goorden, A. Morgenstern, F. Bruchertseifer, K.J. Beekman, M. de Jong, M.W. Konijnenberg, J. Nucl. Med., 2016

  • Ultra-high-sensitive sub-mm mouse SPECT. O. Ivaschchenko, F. van der Have, M.C. Goorden, R.M. Ramakers, F.J. Beekman. J. Nucl. Med. 2015

  • Bench to bedside development of GMP grade Rhenium-188-HEDP, a radiopharmaceutical for targeted treatment of painful bone metastases. R. ter Heine, R. Lange, O.B. Breukels, H.J. Bloemendal, R.G. Rummenie, A.M. Wakker, H. de Graaf, F.J. Beekman, M. van der Westerlaken, M.M. Malingré, J.P.M. Wielders, L. van den Berge, H Hendrikse, J.M.H. de Klerk, Int. J. Pharmaceutics, 2014

  • U-SPECT-BioFluo: an integrated radionuclide, bioluminescence and fluorescence imaging platform. M.N. van Oosterom, R. Kreuger, T. Buckle, W.A. Mahn, A. Bunschoten, L. Josephson, F.W.B. van Leeuwen, F.J. Beekman, Eur. JNM&MI Research, 2014

  • Modelling the physics in iterative reconstruction for transmission computed tomography. J. Nuyts, B. de Man, J.A. Fessler, W. Zbijewski, F.J. Beekman, Phys. Med. Boil., 2012

  • VECTor: A Pre-clinical Imaging System for Simultaneous Sub-mm SPECT-PET. M C. Goorden, F. van der Have, R. Kreuger, R.M. Ramakers, B. Vastenhouw, J.P.H. Burbach, J. Booij, F. J. Beekman. J.Nucl.Med., 2013 

  • V.R. Bom, L. Joulaeizadeh and F.J. Beekman. Real-time prompt gamma monitoring in spot-scanning proton therapy using imaging through a knife-edge-shaped slit. Phys.Med.Biol., 2012

  • B. F. Hutton, I. Buvat, F. J Beekman, Review and current status of SPECT scatter correction, Phys. Med. Biol, 2011

  • W. Branderhorst, B. Vastenhouw and F.J. Beekman. Pixel-based subsets for rapid multi-pinhole SPECT reconstruction. Phys. Med. Biol., 2010

  • B. Vastenhouw, F. van der Have, A.M van der Linden, L. von Oerthel, J. Booij, J.P.H. Burbach, M. P. Smidt, F.J. Beekman. Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT. Mol. Psych, 2007

  • W. Zbijewski and F.J. Beekman, "Efficient Monte Carlo based scatter artifact reduction in cone-beam micro-CT", IEEE Transaction on Medical Imaging, 2006

 

Secondary employment

CEO/CSO & Founder of Free Bee Int’l B.V. te Utrecht

Prof. dr. Freek J. Beekman

Full Professor

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