News

Healthy Start: Increasing opportunities for young people

Scanning a single protein, one amino acid at a time

Using nanopore DNA sequencing technology, researchers from TU Delft and the University of Illinois have managed to scan a single protein: by slowly moving a linearized protein through a tiny nanopore, one amino acid at the time, the researchers were able to read off electric currents that relate to the information content of the protein. The researchers published their proof-of-concept in Science today. The new single-molecule peptide reader marks a breakthrough in protein identification, and opens the way towards single-molecule protein sequencing and cataloguing the proteins inside a single cell.

Mechanism underlying the emergence of virus variants unravelled

An international consortium, led by Delft University of Technology and the University of North Carolina, has for the first time succeeded in probing the molecular origins of recombination in RNA viruses. Hiccups during the copying process of viruses cause recombination to take place: the exchange of segments of viral RNA.

Design for Deaf culture and health

Patients failing to take their medication in the prescribed manner is a widespread problem across society. But a combination of social barriers, discrimination and difficulty with written language mean that the Deaf community has a greater struggle. This medication non-adherence can be dangerous for patients, prolong sickness and strained healthcare systems. Ph.D. researcher Prangnat Chininthorn wanted to find ways to improve this and help Deaf people better manage their own health.

Mapping the brain motor cortex region in detail

In a major study funded by U.S Government, an international consortium of researchers successfully mapped the different types of brain cells in the motor cortex. Scientists from the Leiden University Medical Center (LUMC) and Delft University of Technology (TU Delft) contributed specific expertise to visualize the data.

Researchers unravel molecular replication process of covid-19

Is there a way to stop SARS-CoV-2-? An international consortium, led by biophysicist David Dulin at VU Amsterdam and in collaboration with Martin Depken from TU Delft, has investigated how to interfere with the viral genome-replication process at the molecular level.

Understanding human-robot interaction critical in design of rehabilitation systems

Robotic body-weight support (BWS) devices can play a key role in helping people with neurological disorders to improve their walking. The team that developed the advanced body-weight support device RYSEN in 2018 has since gained more fundamental insight in BWS but also concludes that improvement in this field is necessary.

Stronger is not always better

Rather than one key and one strong lock, biology often uses tens or hundreds of weaker links to bind parts together, such as cells membranes. This allows for selectivity and also reversibility: the binding can also be undone. Researcher Christine Linne and colleagues from Leiden University, TU Delft and Imperial College London first caught this phenomenon using spheres or colloids, and published September 1st in the journal PNAS.

Catch me if you can: a revolutionary method to study single proteins

Researchers from the technical universities of Delft and Munich have invented a new type of molecular trap that can hold a single protein in place for hours to study its natural behavior – a million times longer than before.

New CRISPR-Cas system cuts virus RNA

Researchers from the group of Stan Brouns (Delft University of Technology) have discovered a new CRISPR-Cas system that cuts RNA. The study will be published on August 26 in Science and is expected to offer many opportunities for the development of new applications in genetic research and biotechnology.

A new spin on making minimal cells

The ability of a cell to separate its own matter from its surroundings is a basic requirement for life. A team of researchers at AMOLF and Delft University of Technology have managed to create a synthetic container, or lipid vesicle, that is able to hold a range of different biological systems: from a cytoskeleton to entire E.coli bacteria. Their findings on this optimized cDICE method, which has the potential to reveal the inner workings of life, are published in ACS Synthetic Biology on DATE.

Researchers make 3D image with light microscope

For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.

A new tool to understand the brain

How does our brain work? An international team of researchers, including lead author Daan Brinks of TU Delft, has taken another step towards answering that question. They have created a new tool that allows them to image electrical signals in brains with an unprecedented combination of precision, resolution, sensitivity, and depth.

Researchers in Delft and Eindhoven argue in Science for more ventilation to combat COVID-19

An international group of 39 scientists have published an article in Science arguing for more use of ventilation to combat COVID-19. However, they want to use their argument far more broadly than just the current pandemic, and to combat the spread of all respiratory infections by changing building designs. Philomena Bluyssen from TU Delft and Marcel Loomans from TU Eindhoven are two of the authors. The article was published on Thursday 13 May.

Pandemic & Disaster Preparedness Center openend

The Pandemic & Disaster Preparedness Center (PDPC) was officially opened on Friday May 21 at Erasmus MC. Researchers at the PDPC study future virus outbreaks and disasters to be better prepared.

Researchers discover how a cell’s armour can be both flexible and strong

Medieval knights either had thick, cumbersome armour, or they could wear less protective armour and be flexible in combat – they couldn’t have both. Cells, on the other hand, do have it all. Researchers from Delft University of Technology (TU Delft), Leeds University, Institut Fresnel in Marseille, and Institut Curie in Paris discovered that proteins called ‘septins’ reinforce the fragile membrane of a cell, while still being flexible enough to allow the cell to change shape.

Persuasive technology for health and wellbeing at work

Elsbeth de Korte isn’t your typical Ph.D. student. When she defends her thesis later this month, on how technology can improve health and well-being in the workplace, she will have already been working at the Dutch research institute TNO for more than twenty years.

TU Delft develops ‘stumble tracker’ for trauma surgeon

We’re all familiar with the step tracker these days. Now there’s something new: the stumble tracker. This invention by TU Delft is helping a trauma surgeon at Erasmus MC to measure whether people using a new kind of prosthetic leg stumble less frequently. ‘This partnership has a bright future.’

Chirlmin Joo receives VICI grant for identifying proteins one at a time

Researcher Chirlmin Joo of TU Delft will receive a VICI grant for developing a method to sequence proteins one at a time. He will receive 1.5 million euros from the Netherlands Organisation for Scientific Research (NWO).

Investment from Growth Fund gives Zuid-Holland economy a big boost

Zuid-Holland's economy and knowledge and innovation infrastructure will be strengthened thanks to investments from the National Growth Fund announced today by the demissionary government. The money will go towards improving accessibility, Health, Quantum, Green Power and Artificial Intelligence.

Stopping Alzheimer’s before it starts

This week the Dutch project ABOARD (A personalized medicine approach for Alzheimer’s disease), a collaboration of more than thirty partners, has been launched. ABOARD aims to prepare for a future in which Alzheimer’s disease is stopped before dementia has started. ABOARD achieves this by improving diagnostic markers, developing personalized risk scores and by focusing on prevention through increased awareness of dementia and brain health.

Clever Delft trick enables 20 times faster imaging with electron microscopy

Researchers at TU Delft have expanded upon a clever trick that increases the speed of electron microscope imaging by a factor of twenty. A simple adjustment is all that is needed: applying a voltage to the specimen holder. Through this simple intervention, a specimen that the electron microscope would normally take a week to image can now be inspected in a single night or one working day.

Researchers shed new light on DNA replication

In preparation for cell division, cells need to copy (‘replicate’) the DNA that they contain. A team of researchers from TU Delft, collaborating with investigators from the Francis Crick Institute in London, has now shown that the protein building blocks involved in the initial steps of DNA replication are mobile but reduce their speed at specific DNA sequences on the genome. Their findings, which will be published on 26 March in the open-access journal Nature Communications, were facilitated using an integrated approach involving biophysics and biochemistry that will propel new discoveries in the field.

Decoding movement intentions in the brain using ultrasound waves

An international team of scientists that includes ImPhys researcher David Maresca published an article in Neuron today demonstrating decoding of movement intentions in the brain using ultrasound. The work shows great promises for the development of less invasive brain-machine interfaces.

New test makes detection of genetic material visible to the naked eye

Onderzoekers van de TU Delft hebben een test ontwikkeld waarmee ze specifieke stukjes genetisch materiaal kunnen opsporen, waarna de uitslag met het blote oog af te lezen is. Met de test kunnen onder meer virussen, zoals het coronavirus, en antibioticaresistente bacteriën snel en goedkoop worden gedetecteerd. De resultaten zijn gepubliceerd in Biophysical Journal.