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Publications

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MAiA

Introduction MAIA is an algorithm to integrate multiple genome assemblies. For example, assemblies originating from: Different runs of a de…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/software/maia

Software

Peacock (2017): Phylogenies Visualization library PEDCA (2017): Ploidy Estimation by Dynamic Coverage Analysis GenomeTools (2017):…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/software

Computational Neurobiology

The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/research/computational-neurobiology

Single-cell omics

The most recent breakthrough in genomics is the ability to measure within single cells. Data from hundred thousands, even millions of cells,…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/research/single-cell-omics

Functional genomics

The central dogma, first posed by Francis Crick in 1958, tells that DNA encodes for Genes which are translated into Proteins. Over the last…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/research/functional-genomics

Aging research

Why do some people reach the age of 100 in a healthy condition with no signs of neurodegeneration while others do not. DBL investigates…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/research/aging-research

Microbial genomics

Microbes are pervasive in all aspects of life, society and industry. We are particularly interested in the effects of genotypes on…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/research/microbial-genomics

Genome and transcriptome assembly

Genome and transcriptome assembly Two of our most powerful tools to measure biological processes and the organisms involved are DNA- and…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/research/genome-and-transcriptome-assembly

Pangenomes

Sequence graphs are a intuitive way to represent the variation in a collection of DNA sequence. Sets of sequences scale from homologous…

/ewi/over-de-faculteit/afdelingen/intelligent-systems/pattern-recognition-bioinformatics/the-delft-bioinformatics-lab/research/pangenomes