In situ biofunctionalisation of optical sensor surface
Themes: Life Science & Health, High Tech
Proof of principle
A TRL is a measure to indicate the matureness of a developing technology. When an innovative idea is discovered it is often not directly suitable for application. Usually such novel idea is subjected to further experimentation, testing and prototyping before it can be implemented. The image below shows how to read TRL’s to categorise the innovative ideas.
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Why?
Early diagnosis of diseases is of increasing importance, requiring reliable, sensitive and selective methods. An optical micro ring resonator in a microfluidic system has been developed, enabling in situ biofunctionalisation and regeneration of the sensor.
How?
The resonator surface is in situ functionalised with receptors for specific recognition of the species of interest. Upon recognition the accompanying local change of refractive index is registered. After use the receptors can be easily removed and the sensor is ready for reuse.
When?
A lab scale proof of concept has been successfully completed, proving the high quality and reproducibility. Extension of the applicability of this method to the recognition of other species is ongoing.
Prof. dr. Ernst Sudhölter