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Dragons' Den for biotech

Dragons' Den for biotech The Netherlands is renowned for its leading biotech research, yet it produces an underwhelming number of practical applications. Biotech Booster was designed to shake this up through targeted investment in promising ideas and getting entrepreneurs involved at an early stage. The programme was set up with funding from the National Growth Fund and has been operational since May 2024. Biotech Booster is helmed by biotechnologist Nettie Buitelaar. “We have industry and academia meet at an earlier stage.” Text: Jurjen Slump • Photos: TU Delft, Biotech Booster • November 5, 2024 What was the reason for establishing Biotech Booster? “The Netherlands is at the forefront of biotech from a scientific point of view. Although a large number of publications and registered patents are produced here, fewer new products and services emerge from these novel insights than you might expect. No one really knows why, but a lack of entrepreneurial ambition among academics may play a role. It also often involves a combination of factors such as funding or the lack of good role models.” How are you going to change that? "Biotech Booster is a unique coalition of knowledge institutions and industry. In 2022, we were allocated €246 million from the National Growth Fund to accelerate the transformation of biotechnology knowledge into relevant innovations. We have worked hard to get the organisation up and running since then and expect to admit the first 50 projects to our programme this year." How does Biotech Booster work? “Consisting of three phases, the programme aims to offer both financial support and expertise. We have around 40 business developers traversing the country to scout and mentor promising ideas at research universities, universities of applied sciences and beyond. The goal is for these projects to deliver a proof of principle so that the most promising ideas can be developed into a proof of concept in the next phase. The remaining teams get support and guidance to help commercialise their invention in the scale-out phase. In the first phase, projects can apply for up to €200,000 in funding, with proof of concept projects getting up to €1.9 million." Delft researchers are scaling up sustainable bioprocesses for industrial use in the Zero Emission Biotechnology project. This research programme of the TU Delft specialises in biotechnology for reducing and reusing CO2 emissions, in partnership with industry. What themes are you interested in? We have five thematic clusters: Industrial Biotechnology & Production, Agrifood Biotechnology, ATMPs [advanced therapy medicinal products] and Biopharmaceuticals, Diagnostics and Services, and Vaccines and Small Molecules. TU Delft mainly excels in the first cluster, which is one of the reasons why the manager of the industrial biotech cluster, Cornelis Mijnders, is also based in Delft. The entire innovation ecosystem in Delft - including Planet.bio, Biotech Campus Delft and DSM - has also been linked to Biotech Booster." What makes Biotech Booster unique? “We bring in biotech entrepreneurs at a very early stage and have compiled a pool of 130 top-performing business owners who are involved in projects from the get-go. Proof of concept project proposals also consist of a pitch to our entrepreneurial panel, followed by an extensive round of questions. The independent opinion of our entrepreneurs is decisive, which is our way of ensuring that projects meet market needs and wishes. We also involve experts at an early stage who assist us with issues such as the compliance of new drugs with various laws, regulations and requirements, which researchers often know little about.” Nettie Buitelaar Dr. ir. Nettie Buitelaar MBA is a biotechnologist with years of experience in both business and leading public-private partnerships. She has been the director of the Leiden Bio Science Park and director of the successful BioPartner programme from which dozens of new biotech companies have emerged. So you’re more than just an investor? “Our programme marks the first time that all the different parts of the Dutch biotech sector have joined forces. And that is just fantastic! While industry and academia were never entirely separate worlds, Biotech Booster brings the two together at a very early stage. The programme is intended to be and remain a learning system but we must also stimulate entrepreneurship in academia. If you ask me, every researcher has a duty to consider whether their findings can make an impact outside academia." But has there been a return on investment? “Absolutely. We lose our money when a project fails. But if a team advances to the proof of concept phase and decides to bring in other investors, we’ll want to recoup some of our investment because we gave them the push that enabled them to take that step. The same applies to projects leading to an exit. Over time, Biotech Booster will need to be funded with the programme’s own proceeds, which we can then use to support subsequent projects. This would enable us to continue under our own steam when the grant from the Growth Fund ends after 2031." What biotech breakthroughs do you expect in the coming years? What radical innovations will we see? “It’s too early to tell, but there are a few clear trends. A lot is happening around ATMPs, drugs for cell therapy, gene therapy and tissue engineering. Many steps can also be taken in the field of production processes involving fermentation to produce more efficiently with less waste. Circularity is an important issue in all areas." The National Growth Fund has been discontinued and the new government has announced plans to cut higher education spending. How does this affect innovation? “You have to realise that cutting back on scientific research will lead to the gradual depletion of the valorisation pipeline, resulting in fewer new products and less new knowledge. Our future prosperity will inevitably be affected, which was exactly why the National Growth Fund was set up in the first place - so it could contribute to the country’s long-term earning capacity. Hacking at the roots affects the entire tree.” Interested in business collaboration? Contact us Order the newest magazine Featured article ‘If you never try, you'll never know.’ Pioneering articles

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How storm surge barriers can keep the Netherlands safe and liveable

A safe and liveable delta, who doesn't go for that? Storm surge barriers play a crucial role in this. Yet there are many choices to be made in the short term to keep the storm surge barriers in a good condition, to eventually cope with rising sea levels in the longer term. A new project receives funding from NWO for five years to explore the best routes to a liveable delta. Storm surge barriers, like the Maeslantkering and the Oosterscheldekering are essential for protecting the Netherlands from high water coming in from the sea. How long will these imposing structures remain effective bearing in mind sea level rise, decay of the structures and an altering surrounding area. In the short term, decisions will have to be taken on maintenance, while in the longer term, adaptation or replacement should be considered. Linking storm surge barriers with the delta Within the SSB-Δ (storm surge barrier delta) project, a diverse consortium will investigate under what circumstances storm surge barriers can keep the Netherlands safe and liveable. The consortium consists of the universities of Delft, Utrecht, and Rotterdam; the universities of applied sciences of Rotterdam and Zeeland; knowledge institutes Deltares and TNO, as well as Rijkswaterstaat, water boards and companies. Bram van Prooijen, associate professor at TU Delft, will lead the research: “Decisions on flood defences are important for the entire delta. The link between the hinterland and the flood defences needs to be made properly. During this project, we will have the opportunity to bring different areas of expertise together and strengthen each other.” Long term perspective Therefore, the research is not only about the technical lifespan of the barriers. It will also clarify how the delta is going to change and how society thinks about it, resulting in a guideline to on how and when decisions need to be taken in the short term, with a long term perspective. Van Prooijen cites an example of car maintenance: “Think of replacing the engine block. This is very expensive maintenance, but sometimes necessary to keep the car running safely. But is it worth the investment if you plan to buy a new car next year? Or if you prefer to travel by train? Important choices will have to be made for storm surge barriers. We want to provide a strong basis for that.” Informed decisions The project will reveal the possible pathways to a liveable delta, and how storm surge barriers fit into that. Van Prooijen: “That offers clarity, to make quick and better-informed decisions. Many trials run for a long time, with the outcome of this research we can decide which trials specifically are the best option to proceed with.” Future experts One of the storm surge barriers involved in the research is the Maeslantkering. This barrier is expected to last another fifty years or so. That may seem far away, Van Prooijen reasons, “but we need to train the experts who will decide on this now. Those are probably the PhD students on this project.”

Researchers hand over Position Paper to Tweede Kamer

On behalf of the TU Delft PowerWeb Institute, researchers Kenneth Brunninx and Simon Tindemans are handing over a Position Paper to the Dutch Parliament on 14 November 2024, with a possible solution to the major grid capacity problems that are increasingly cropping up in the Netherlands. The Netherlands is unlikely to meet the 2030 climate targets, and one of the reasons for this is that large industry cannot switch to electricity fast enough, partly because of increasingly frequent problems around grid capacity and grid congestion. In all likelihood, those problems will actually increase this decade before they can decrease, the researchers argue. The solution offered by the TU Delft PowerWeb Institute researchers is the ‘flexible backstop’. With a flexible backstop, the current capacity of the power grid can be used more efficiently without sacrificing safety or reliability. A flexible backstop is a safety mechanism that automatically and quickly reduces the amount of electricity that an electric unit can draw from the grid (an electric charging station or a heat pump) or deliver (a PV installation). It is a small device connected or built into an electrical unit, such as a charging station or heat pump, that ‘communicates’ with the distribution network operator. In case of extreme stress on the network, the network operator sends a signal to the device to limit the amount of power. Germany recently introduced a similar system with electric charging stations. The backstop would be activated only in periods of acute congestion problems and could help prevent the last resort measure, which is cutting off electricity to users. ‘Upgrading the electricity network remains essential, but in practice it will take years. So there is a need for short-term solutions that can be integrated into long-term planning. We, the members of the TU Delft PowerWeb Institute, call on the government, network operators and regulator to explore the flexible backstop as an additional grid security measure,’ they said. The entire Paper can be read here . Kenneth Brunninx Associate Professor at the Faculty of Engineering, Governance and Management, where he uses quantitative models to evaluate energy policy and market design with the aim of reducing CO2 emissions. Simon Tindemans is Associate Professor in the Intelligent Electrical Power Grids group at Faculty of Electrical Engineering, Mathematics and Computer Science. His research interests include uncertainty and risk management for power grids. TU Delft PowerWeb Institute is a community of researchers who are investigating how to make renewable energy systems reliable, future proof and accessible to everyone.