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Imaging Physics

The department of Imaging Physics develops novel instrumentation and imaging technologies. We are driven by our scientific curiosity and problem oriented nature in research with a strong connection to industry and to educate future leaders in the field of imaging science.

The scientific staff of the department is formed by independent Principal Investigators or Educators.

News

Early attempt at colour photography discovered

Delft University of Technology has unearthed six glass slides (1890 – 1910), which represent one of the earliest attempts at colour photography. The slides were found during an inventory conducted by the Programme Tailor-Made Approach to Faculty Collections at the Imaging Physics department of the Faculty of Applied Sciences. To view the images, technician Thim Zuidwijk reconstructed a diffraction chromoscope, revealing vivid depictions of a vase with a floral motif and a still life of a fruit basket alongside a banana and a wrapped citrus fruit.

Revolutionary terahertz spectrometer: a step forward in space observation

Researchers at Delft University of Technology (TU Delft), in close collaboration with SRON Netherlands Institute for Space Research and LongWave Photonics LLC, have achieved a breakthrough in terahertz spectroscopy—a vital technology to study galaxies, stars, and planetary formation. They created a centimeter-sized, lightweight terahertz spectrometer that could replace traditional half-meter-sized, bulky, and heavy spectrometers in future space observatories. The new device could significantly reduce costs and offer greater flexibility in launching, making these space observatories more affordable and feasible. The innovation is published in Laser & Photonics Reviews.

Start Medical Delta Program ‘‘Advanced brain imaging for diagnosis and prediction of dementia’

The programme aims to make an accurate distinction between people with a high and low risk of dementia outside the hospital. For high-risk patients, the program then aims to provide faster and more accurate diagnoses with advanced imaging and image analysis techniques. The goal is to use analysis tools effectively, sustainably and affordably, and to determine which test is most suitable for whom and when.

Start Medical Delta Program ‘Cancer diagnostics for sustainable health care (CARES)’

The developments within this programme contribute to a more sustainable and affordable healthcare system by means of earlier cancer diagnoses, (quantitative) indications and more efficient treatments for only those cancer patients who will actually benefit from them.

Cover article Nature Light: Science & Applications | Computational Imaging for EUV wafer metrology

The paper EUV wafer metrology using computational imaging method “ptychography” has been selected by Nature Light: Science & Applications as the cover article for the next issue to be published on 31 October.

Mark Vermeulen joined ImPhys as PhD student

Mark Vermeulen is a new PhD student in the Menzel group. He will focus on the theoretical analysis and image processing of light scattering signals.

Qiao-Ling Wang joined ImPhys as MSc student

Qiao-Ling will be doing her master thesis under the supervision of Bernd Rieger. The topic is on estimating the localization and orientation of single molecules in the 4pi microscope setup.

Julie Raude joined ImPhys as MSc student

Julie Raude is an applied physics master student. She is starting her master thesis project in the lab of Jacob Hoogenboom with Stijn Karaçoban as daily supervisor. The project is about imaging a sample with higher resolution using an ion beam miller with an electron microscope.
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In the spotlight

In the spotlight

Nieuw zicht op vervlochten zenuwvezels

De hersenen bevatten miljoenen zenuwvezels die dicht op elkaar gepakt zijn, waardoor het lastig is om de vezels van elkaar te onderscheiden met microscopische technieken. Miriam Menzel ontwikkelde een eenvoudige lichtmicroscopietechniek die de oriëntatie van deze vezels in beeld kan brengen.

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Pushing boundaries to inspect increasingly small computer chips

There is a growing demand for smaller and more powerful computer chips. A major challenge to meet this demand is that when components are extremely small, it is hard to make them visible and inspect with light. By using electrons instead of light, the highest possible resolution can be achieved for visualising semiconductor components. Inspection with electrons offers a solution, but the technique still has major, fundamental shortcomings. Get on board: join this research collaboration between ARCNL, TU Delft and ASML -> PhD & Postdoc positions

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Advanced microscopy to understand life and fight disease

In the NL-BI consortium, scientists from all Dutch academic research centres will together develop and integrate state-of-the-art microscopy with technologies and services in different nodes. This will enable access for all scientists to revolutionise fundamental insights into the building blocks of life, enable scientific breakthroughs, and advance applications towards society for overcoming life-threatening disease, including cancer, metabolic, cardiovascular, and neurodegenerative disorders.

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Pushing the boundaries of ultrasound

Physicist David Maresca has received a Chan Zuckerberg Initiative Dynamic Imaging grant to develop a next-generation medical ultrasound tool. While state-of-the-art ultrasound imaging, known to most as a baby’s first picture, can show our anatomy and organs, the new tool will be able to zoom in much further, all the way down to the level of the cells in our body. Maresca: “Ultrasound is a safe but also affordable and widespread technology. If we can push the boundaries and make it more sensitive, it will potentially help a lot of people.”

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Microscope shows researchers the way to proteins

Physicists from TU Delft, Daan Boltje and Jacob Hoogenboom have developed a 3-in-1 microscope where a light beam, electron beam and ion beam work together to precisely cut out specific slices from biological samples. These slices are indispensable for biomolecular research into new generations of medicines.

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Spying on microscopic blood vessels in the heart and brain

Sebastian Weingärtner will use Magnetic Resonance Imaging (MRI) to exploit hydrogen atoms as microscopic spies to investigate the smallest blood vessels in the body. These ultra-small blood vessels are so fine that they evaded medical imaging so far, yet a better understanding of their features could be a transformative step towards better treatment of diseases like heart failure and dementia.

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From light spots to supersharp images

Making detailed 3D images of proteins in living cells with a special light microscope, without damaging those cells. That is what Sjoerd Stallinga, winner of an ERC Advanced grant worth 2.3 million euros, wants to achieve. In order to do so he is going to scan samples nanometer by nanometer using a sophisticated 3D light pattern in an approach that requires extensive collaboration between different disciplines.

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Spotlight on aggressive cancer cells

Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumour. Miao-Ping Chien and Daan Brinks are working together, from two different universities, on a method to detect these cells. Their research has now been published in Nature Biomedical Engineering

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How to find structurally different molecules before they disappear in the average?

Particle fusion for single molecule localization microscopy improves signal-to-noise ratio and overcomes underlabeling, but ignores structural heterogeneity or conformational variability. This study presents a-priori knowledge-free unsupervised classification of structurally different particles employing the Bhattacharya cost function as dissimilarity metric.

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The impact of noise on Structured Illumination Microscopy image reconstructions

Super-resolution structured illumination microscopy (SIM) has become a widely used method for biological imaging. Standard reconstruction algorithms, however, are prone to generate noise-specific artifacts that limit their applicability for lower signal-to-noise data. Here we present a physically realistic noise model that explains the structured noise artifact, which we then use to motivate new complementary reconstruction approaches.

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A new tool to understand the brain

How does our brain work? An international team of researchers, including lead author Daan Brinks of TU Delft, has taken another step towards answering that question. They have created a new tool that allows them to image electrical signals in brains with an unprecedented combination of precision, resolution, sensitivity, and depth.

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Researchers make 3D image with light microscope

For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.

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Decoding movement intentions in the brain using ultrasound waves

While many techniques can image brain activity, this was the first time that a new technology, called functional ultrasound imaging, was used to detect motor planning deep within the brain. The team is now applying functional ultrasound decoding to more complicated motor control tasks. At ImPhys, Dr. Maresca is developing ultrasound technologies to image brain activity down to the cellular scale.

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